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《医学前沿(英文)》 doi: 10.1007/s11684-023-1001-2
关键词: iron deficiency anemia intravenous iron ferric carboxymaltose iron sucrose Hb response early response
《医学前沿(英文)》 2022年 第16卷 第5期 页码 736-744 doi: 10.1007/s11684-021-0870-5
关键词: pneumoconiosis randomized controlled trials traditional Chinese medicine
null
《医学前沿(英文)》 2014年 第8卷 第3期 页码 368-375 doi: 10.1007/s11684-014-0360-0
This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-Pi granules, Bu-Fei Yi-Shen granules, and Yi-Qi Zi-Shen granules based on TCM patterns respectively; and the control group treated using conventional western medicine. A total of 136 patients≥65 years completed the study, with 63 patients comprising the trial group and 73 comprising the control group. After the six-month treatment and the 12-month follow-up period, significant differences were observed between the trial and control groups in the following aspects: frequency of acute exacerbation (P≤0.040), duration of acute exacerbation (P = 0.034), symptoms (P≤0.034), 6-min walking distance (6MWD) (P≤0.039), dyspnea scale (P≤0.036); physical domain (P≤0.019), psychological domain (P≤0.033), social domain (P≤0.020), and environmental domain (P≤0.044) of the WHOQOL-BREF questionnaire; and daily living ability domain (P≤0.007), social activity domain (P≤0.018), depression symptoms domain (P≤0.025), and anxiety symptoms domain (P≤0.037) of the COPD-QOL. No differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%.
关键词: chronic obstructive pulmonary disease older adult clinical trial Bu-Fei Jian-Pi granules Bu-Fei Yi-Shen granules Yi-Qi Zi-Shen granules
《医学前沿(英文)》 2021年 第15卷 第3期 页码 460-471 doi: 10.1007/s11684-021-0861-6
关键词: low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose
《医学前沿(英文)》 2022年 第16卷 第5期 页码 745-759 doi: 10.1007/s11684-021-0880-3
关键词: insulin resistance non-alcoholic fatty liver disease Chinese herbal medicine randomized controlled trial DNA N6-methyladenine modification
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 340-349 doi: 10.1007/s11684-017-0565-0
Benralizumab is a monoclonal antibody that targets interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthma. We conducted a meta-analysis to evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthma. All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthma, which were searched in PubMed, Embase, and the Cochrane Library published until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthma control, quality of life scores, and adverse events were included. Randomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative risks, and 95% confidence intervals. Five studies involving 1951 patients were identified. Compared with the placebo, benralizumab treatment demonstrated significant improvements in the forced expiratory volume in 1?s (FEV1), Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control Questionnaire-6 (ACQ-6) scores. Benralizumab treatment was also not associated with increased adverse events. These findings indicated that benralizumab can be safely used to improve FEV1, enhance patient symptom control and quality of life, and reduce the risk of exacerbations and ACQ-6 scores in patients with eosinophilic asthma. Furthermore, our meta-analysis showed that benralizumab with 30 mg (every eight weeks) dosage can improve the health-related quality of life and appear to be more effective than 30 mg (every four weeks) dosage. Overall, data indicated that the optimal dosing regimen for benralizumab was possibly 30 mg (every eight weeks).
关键词: benralizumab anti-interleukin-5 monoclonal antibody eosinophilic asthma meta-analysis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 93-104 doi: 10.1007/s11684-021-0892-z
关键词: chemotherapy cervical cancer lymph node metastasis concurrent chemoradiotherapy quality of life
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 112-116 doi: 10.1007/s11684-010-0016-7
关键词: cervical cancer radical surgery peritoneum subcutaneous tissue
《医学前沿(英文)》 2022年 第16卷 第2期 页码 276-284 doi: 10.1007/s11684-021-0855-4
关键词: gestational trophoblastic neoplasia (GTN) methotrexate (MTX) dactinomycin (ACTD)
Shilin DENG MD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 323-329 doi: 10.1007/s11684-009-0061-2
关键词: early postmenopausal women bone mineral density exercise effects
Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang
《医学前沿(英文)》 2021年 第15卷 第5期 页码 704-717 doi: 10.1007/s11684-021-0853-6
关键词: COVID-19 SARS-CoV-2 Shuanghuanglian oral liquid clinical trial
植物乳杆菌CCFM8610缓解肠易激综合征并改善肠道菌群失调——一项随机、双盲、安慰剂对照的先导性临床试验 Article
刘洋, 郁辛杰, 于雷雷, 田丰伟, 赵建新, 张灏, 钱龙, 王群, 薛正青, 翟齐啸, 陈卫
《工程(英文)》 2021年 第7卷 第3期 页码 376-385 doi: 10.1016/j.eng.2020.06.026
腹泻型肠易激综合征(irritable bowel syndrome with diarrhea, IBS-D)是一种伴有腹泻等复杂临床症状的慢性肠功能障碍,对患者的日常生活和精神状态具有极大影响。一些研究报道称,摄入益生菌可显著缓解多种肠道疾病。本研究的目的是探究一株具有多种保健作用的益生植物乳杆菌(Lactobacillus plantarum)CCFM8610对IBS-D的缓解作用。这项研究是一项为期12周的随机、双盲、安慰剂对照的先导性临床试验。75名患者被随机分配接受安慰剂、低聚糖或植物乳杆菌CCFM8610 [每天1 × 1010 CFU(菌落形成单位)],进行为期两周的观察、8周的干预及两周的后续随访。采用IBS症状严重程度量表(IBS-SSS)及IBS生活质量量表(IBS-QOL)评定患者的临床症状和生活质量。在干预期结束时,测定肠道菌群组成和多样性的变化。结果表明,口服植物乳杆菌CCFM8610显著降低了IBS-SSS和IBS-QOL评分,减轻了IBS-D症状的严重程度,恢复了肠道菌群的多样性,降低了与腹胀相关的甲烷短杆菌属(Methanobrevibacter)的相对丰度,增加了厌氧棒状菌属(Anaerostipes)、双歧杆菌属(Bifidobacterium)、丁酸弧菌属(Butyricimonas)及臭杆菌属(Odoribacter)等丁酸生产种属的相对丰度。这些结果表明,摄入植物乳杆菌CCFM8610可以显著缓解IBS-D患者的临床症状及肠道菌群失调。植物乳杆菌CCFM8610对IBS-D的缓解作用可能与肠道中丁酸生产种属的相对丰度上升有关。
长双歧杆菌CCFM1077通过调节肠道微生物组成和粪便代谢物来减轻高脂血症——一项随机、双盲、安慰剂对照的临床试验 Article
储传奇, 姜金池, 于雷雷, 李易文, 张松礼, 周巍, 王群, 赵建新, 翟齐啸, 田丰伟, 陈卫
《工程(英文)》 2023年 第28卷 第9期 页码 193-205 doi: 10.1016/j.eng.2023.04.010
越来越多的研究表明肠道菌群及其代谢物在高脂血症的发展中至关重要。长双歧杆菌(Bifidobacterium longum, B. longum)CCFM1077已在动物中显示出降脂作用。本研究旨在评估B. longum CCFM1077在降低高脂血症患者血脂水平方面的潜力,并调查该菌对患者的血清脂质异常、肠道菌群和粪便代谢物的影响。本研究是一个为期六周的随机、双盲、安慰剂对照的试验。高脂血症患者(N = 62)被随机分配接受安慰剂(N = 31)或B. longum CCFM1077 [每日1.0×1010个菌落形成单位(CFU);N = 31]。在基线和干预终点检查了包括总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、总甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)在内的血清脂质水平。肠道菌群组成和多样性的变化是基于16S核糖体RNA(rRNA)V3~V4区域的测序在干预期结束时进行。利用超高效液相色谱(UPLC)-Q-Exactive Orbitrap/质谱仪进行了粪便的非靶向代谢组学分析。口服B. longum CCFM1077六周显著降低了高脂血症患者的血清TC(p < 0.01)和LDL-C(p < 0.01)水平。B. longum CCFM1077的治疗显著增加了肠道菌群的多样性和抗肥胖相关属的相对丰度,包括Lactobacillus、Butyricicoccus、Bifidobacterium和Blautia,而减少了与肥胖相关属的相对丰度,包括Alistipes、Megamonas和Catenibacterium。此外,一些关键代谢产物[胆汁酸(BA)、生物素和咖啡因]及其相应的代谢途径(主要胆汁酸生物合成,牛磺酸和次牛磺酸代谢,生物素代谢,嘌呤代谢和咖啡因代谢)被B. longum CCFM1077富集,因此可能降低血脂水平。B. longum CCFM1077是一种具有降低高脂血症患者血清TC和LDL-C水平潜力的益生菌菌株。其潜在机制可能与抗肥胖相关属和粪便代谢物的增加有关。这些发现为将来在管理高脂血症患者中应用益生菌奠定了基础。
Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu
《医学前沿(英文)》 2021年 第15卷 第3期 页码 486-494 doi: 10.1007/s11684-020-0824-3
关键词: tocilizumab coronavirus disease 2019 (COVID-19) cytokine storm
特力阿扎维林治疗新冠病毒肺炎的疗效和安全性——一项随机对照试验 Article
吴效科, 于凯江, 王永晨, 徐万海, 马红丽, 侯艳, 李悦, 蔡本志, 朱丽影, 张敏, 胡晓丽, 高敬书, 王宇, 秦慧超, 王文杰, 赵鸣雁, 吴霞, 张勇, 李璐, 李康, 杜智敏, Ben Willem J. Mol, 杨宝峰
《工程(英文)》 2020年 第6卷 第10期 页码 1185-1191 doi: 10.1016/j.eng.2020.08.011
目前,尚无有效疗法可治愈由新型冠状病毒(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)引起的新型冠状病毒肺炎(coronavirus disease 2019, COVID-19)。为了评估抗病毒药物特力阿扎维林治疗COVID-19的有效性和安全性,本研究针对感染COVID-19的成年住院患者开展了一项随机双盲对照试验。本研究从10个分中心招募COVID-19患者,并将患者按1:1的比例随机分为两组。试验组的患者每天服用250 mg的特力阿扎维林药物3~4次,对照组患者则服用安慰剂,为期共7 d。主要结局指标为临床改善时间,临床改善时间的定义为随机分组28 d内患者的体温、呼吸频率、血氧饱和度、咳嗽频率和肺CT(计算机断层扫描,computed tomography)所显示的肺部感染吸收情况全部恢复正常的时间。次要结局指标包括主要结局指标的各个组成成分,如肺部感染吸收的平均时间和吸收比例,以及用咽拭子采样法连续2次SARS-CoV-2核酸检测阴性的转阴率。与此同时,记录合并的治疗药物、不良事件和严重不良事件。由于需要进行住院治疗的新增感染病例的减少,本研究在招募52名患者后便停止招募。将52名患者随机分为服用特力阿扎维林药物的试验组(n = 26)和服用安慰剂的对照组(n = 26)。结果显示,两组临床改善时间并无明显差异[中位数,7 d vs. 12 d;风险比(RR)为2.0;95%置信区间(CI)为0.7~5.6;p = 0.2]。服用特力阿扎维林的试验组中有10例患者发生临床改善,服用安慰剂的对照组中有6例患者出现临床改善(38.5% vs. 23.1%,RR为2.1;95%CI为0.6~7.0;p = 0.2)。除了肺部感染的吸收情况外(试验组50.0%,对照组26.1%),其余主要结局指标的所有指标均在28 d内恢复正常。此外,试验组的患者对呼吸系统、心脏、肾、肝或凝血功能等方面的的合并治疗较对照组少。尽管特力阿扎维林药物对COVID-19患者的疗效尚未达到统计学上的显著性水平,但本研究结果表明,由于特力阿扎维林药物具有抗病毒作用,将其用于COVID-19的治疗也可能具有一定的疗效。对此,需要进一步的研究来予以证明和确认。
标题 作者 时间 类型 操作
A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus
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based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study
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older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study
null
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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomizedclinical trial
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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach
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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomizedplacebo-controlled trials
null
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versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial
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Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlledtrial
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
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versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomizedclinical trial
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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial
Shilin DENG MD ,
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Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial
Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang
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植物乳杆菌CCFM8610缓解肠易激综合征并改善肠道菌群失调——一项随机、双盲、安慰剂对照的先导性临床试验
刘洋, 郁辛杰, 于雷雷, 田丰伟, 赵建新, 张灏, 钱龙, 王群, 薛正青, 翟齐啸, 陈卫
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长双歧杆菌CCFM1077通过调节肠道微生物组成和粪便代谢物来减轻高脂血症——一项随机、双盲、安慰剂对照的临床试验
储传奇, 姜金池, 于雷雷, 李易文, 张松礼, 周巍, 王群, 赵建新, 翟齐啸, 田丰伟, 陈卫
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Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicentertrial
Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu
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